【摘要】 文章为研究亚麻木脂素对小鼠免疫功能的影响,选用雌雄各半,体重18～22 g的ICR小鼠120只,随机分为对照组和试验低、中、高3个剂量组,小鼠分别经口给予0.6,1.2,3.6 g.kg-1.d-1的木脂素(SDG),持续30 d后测其各项免疫指标,结果表明,3个剂量组的小鼠T淋巴细胞中IL-2细胞活性分别提高57.8%、64.2%、67.4%;巨噬细胞吞噬水平分别提高55.4%、57.0%、59.7%,与对照组比较差异显著(P<0.05,P<0.01);中、高剂量组可使小鼠脾淋巴细胞转化率分别提高58.9%、62.3%;溶血空斑数分别增加51.8%、53.1%;NK细胞活性分别提高58.9%、62.7%,与对照组比较差异显著(P<0.05,P<0.01)。结果表明木脂素具有增强小鼠免疫功能的作用。更多还原

【Abstract】 In order to study the effect of SDG(Secoisolariciresinol diglucoside) in linseed cake on a mouse imm-unologic function,120 ICR mice with body weight 18-22 g,half male and female occupied,were divided into a control group and three experimental groups with low(0.6 g·kg-1·d-1),medium(1.2 g·kg-1·d-1),high(3.6 g·kg-1·d-1)dosage respectively.Separately feeding 0.6,1.2,3.6 g·kg-1·d-1 SDG to three dosage groups of mice and 30 d later,measuring all immunity indexes of mice.The results showed that IL-2 actives of T lymphocyte of three groups increased 57.8%,64.2%,67.4% respectively,phagocytosis of macrophage increased 55.4%,57.0%,59.7% respectively,and the differences were significant(P<0.05,P<0.01)for those mice of 1.2,3.6 g·kg-1·d-1 dosage groups,lymphocyte transformation rate increased 58.9%,62.3% respectively,the hemolysis plague number increased 51.8%,53.1% respectively,the activity of NK cells increased 58.9%,62.7% respectively.The results indicated that SDG could enhance the immunologic function of mice.更多还原