【摘要】 目的研究烫伤休克大鼠液体复苏时给予卡巴胆碱对脏器血流量的影响。方法W istar大鼠分为4组:假烫组,单烫组,烫伤+补液组,烫伤+补液+卡巴胆碱组。采用35%体表面积Ⅲ°烫伤模型(100℃,12秒),应用激光多谱勒测定伤前及伤后4、8、12小时肝、肾、肠组织血流量的改变。结果烫伤后各组脏器血流量均较假烫组显著降低(P<0.01),卡巴胆碱治疗组较烫伤补液组各脏器血流量均显著升高(P<0.01)。结论卡巴胆碱能改善休克早期脏器血流量,有助于烧伤休克及并发症的防治。更多还原

【Abstract】 Objective To investigate the effects of carbachol on the changes of visceral blood flow in rats with scalded injury.Methods Wistar rats were randomly divided into four groups: sham scalded,scalded and scalded with resuscitation,scalded with resuscitation plus carbachol group.Rats were scalded with water of 100℃ for 12 Sec to produce burn model of 35% total body surface area(TBSA) Ⅲdegree,the laser doppler technique was used to determine the blood flow in liver,kidney and intestinal mucosal before scald and at 4,8,12h after scald.Results Visceral blood flow decreased sharply after scalded injury(P<0.01),carbachol treatment resulted in significant recovery of blood flow in animals in carbachol group as compared with those in the other scalded groups.Conclusion Carbachol can improve visceral blood flow in rats with scalded injury,and it might be beneficial to the early treatment of burn shock.更多还原