【摘要】 利用rhBMP-2具有骨诱导作用,采用混合法将rhBMP-2载入到磷酸钙骨水泥(CPC)中,旨在通过CPC协同形成高效骨修复材料。用XRD和SEM检测了其理化特性,同时也测量含rhBMP-2CPC的抗压强度、固化时间和生物力学强度。并对该材料进行动物体内实验。结果表明:rhBMP-2载入对CPC固化时间、抗压强度、物相组成无明显影响。但是,体内实验表明:rhBMP-2的加入使CPC材料能更好的发挥其良好的骨诱导性和骨传导性。更多还原

【Abstract】 Self-setting CPC/rhBMP-2 composite pellet was constructed.It is known that rhBMP-2 plays a function of osteoconduction in bone growth.The study was to develop a good utility Skeletal repair material by incorporating calcium phosphate cement(CPC)and rhBMP-2.The physics and chemistry performance of the new Skeletal repair material was examined with X-ray Diffraction(XRD)and Scanning electron microscope(SEM).The compressive intensity,solidified time and biomechanics intensity also were examined.The prepared material was studied in vivo.The results show that adding rhBMP-2 to CPC has no influence on CPC’s compressive intensity,solidify time and phase composition.It means that rhBMP-2 has no influence on the physics and chemistry performance of CPC either,but the result of in vivo study indicates that CPC with rhBMP-2 composite shows better osteoconduction and osteoinducement than CPC.更多还原