【摘要】 葛根素(Puerarin)临床应用广泛,但是其水溶性低,影响疗效的更好发挥。将葛根素键合到具有良好生物相容性、可降解的水溶性聚天冬酰胺衍生物(PDHEA)上,合成了葛根素前药(PDHEA-P),并通过FT-IR、1H-NMR验证了目标产物。研究表明,葛根素前药的水溶性大大提高,所得前药的缓释性能良好。更多还原

【Abstract】 The low solubility of puerarin in water leads to its poor bioavailability as an oral drug. In this article,the polymer prodrug of puerarin(PDHEA-P) is synthesized by using polyaspartamide derivatives(PDHEA) which have characteristics of biocompatibility,degradation and good solubility in water as drug carrier. The chemical structures of the prodrug are identified by FT-IR and 1H-NMR. Results show that the solubility of prodrug in water is increased greatly,and the release rate is satisfactory.更多还原