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一种可促进成骨细胞黏附和生长的聚乙二醇接枝聚乳酸材料
A New Poly(Ethylene Glycol) Grafted Poly(D,L-lactic acid) with Anti-nonspecific Protein Absorption Property Improving Adhesion and Protiferation of Osteoblasts
【摘要】 用氨基封端聚乙二醇(H2N-PEG-NH2)对聚乳酸(PLA)进行了本体改性,通过FITC荧光标记牛血清白蛋白(FITC-BSA)对材料的抗非特异性蛋白吸附性能进行了检测,在材料上体外培养Wistar大鼠成骨细胞,检测了材料的细胞相容性。结果表明:与聚乳酸相比,得到的产物聚乙二醇改性聚乳酸(PPLA)明显降低了对牛血清白蛋白的非特异性吸附,仅为PLA的37.3%,显著促进了成骨细胞的黏附和生长。由于该材料具有良好的亲水性、可降解性、细胞相容性及可反应性,预计在组织工程和药物缓释中有潜在应用。
【Abstract】 With maleic anhydride grafted PLA(MPLA)as raw material,o,o’-Bis-(2-aminopropyl)polypropylene glycol-block-polyethylene oxide-block-polypropylene glycol(H2N-PEG-NH2,Mw 600)is covalently grafted onto MPLA and results in a new PEG grafted PLA,which is PPLA.Compared with PLA,it has marked anti-nonspecific protein absorption property and improves the adhesion and proliferation of osteoblasts.For its good hydrophilicity,degradability,reactivity as well as cellular compatibility,it can be predicted that it has broad applications in tissue engineering and drug delivery.
【Key words】 poly(D； L-lactic acid)； poly(ethylene glycol)； anti-nonspecific protein absorption property； cellular compatibility；
- 【文献出处】 材料导报 ,Materials Review , 编辑部邮箱 ,2008年08期
- 【分类号】R318.08
- 【被引频次】8
- 【下载频次】256