【摘要】 利用α-氨基、α-羧基均被保护的天冬氨酸或谷氨酸的非α-羧基与中间体N-取代的3,4-富勒烯吡咯烷衍生物的活化羟基进行缩合反应,产物脱保护后得到了2种新的α-富勒烯氨基酸:富勒烯天冬氨酸和富勒烯谷氨酸。采用MALDI-TOF质谱、红外光谱、紫外可见光谱、1HNMR等方法对它们进行了结构表征。合成的新型富勒烯氨基酸含有游离的氨基、羧基,具有独特的化学结构和性质,在生物医学领域具有潜在的应用前景。更多还原

【Abstract】 Aspartic acid or glutamic acid with protected α-amino and α-carboxyl groups is used to react with the activated hydroxyl group of N-substituted 3,4-fullero pyrrolidine.Then the products are deprotected,and afford two novel fullerene α-amino acids,fullerene aspartic acid and fullerene glutamic acid.Their chemical structures are characterized by MALAI-TOF-MS,UV-Vis,IR and 1HNMR.They have a potential application prospect in biomedical field.更多还原