【摘要】 目的:针对溃疡性结肠炎,以苦参提取物为原料,研究结肠康微丸的制备工艺。方法:在微丸制备工艺的研究中,运用锅包衣法,以微丸外观、水分含量、溶解时限、休止角和堆密度为指标,对微丸制备辅料的种类和用量进行考察,筛选出微丸最佳制备工艺条件。结果:微丸制备选择以100%羧甲基淀粉钠作为赋形剂,50%乙醇为润湿剂,包衣转速45 r/m in,进风温度30℃,采用泛制法制备微丸。结论:该微丸制备重复性良好,工艺稳定,可行。更多还原

【Abstract】 Objective: In view of Ulcerative Colitis,we use Oxymatrine extract as raw materials to study on colon Positioning Prepare Technics of Jie Changkang pellets.Methods:In the research,we use Pan coating method,based on the determination target of pellets outward appearance,moisture content,dissolved time,the rest angle and bulk density to decide the best colon Positioning Prepare Technics conditions.Results:Pellets molding choose to 100% sodium carboxymethyl starch as excipients,50% ethanol for wetting agent,coating speed of 45 rpm,intake air temperature 30℃,prepared by the Pan-system pellets.Conclusion: The best processed condition that elects is steady and feasible.更多还原