【摘要】 目的:评估检测癌胚抗原mRNA(CEA mRNA)和端粒酶活性(TA)鉴别诊断恶性腹液的临床应用价值。方法:分别检测105份恶性腹液标本和103份良性腹液标本的CEAmRNA、TA、糖链抗原19-9(CA19-9)和癌胚抗原(CEA)。结果:恶性腹液组各指标的阳性率均明显高于良性腹液组(P<0.01)。CEAmRNA和TA诊断恶性腹液的敏感性和准确性高于CA19-9和CEA,CEAmRNA+TA+CA19-9联检组合的诊断效率最高。结论:CEA mRNA和TA的诊断恶性腹液的应用价值高于CA19-9和CEA,指标的联合实验可提高诊断效率。更多还原

【Abstract】 Objective:To evaluate the clinical value of detecting CEA mRNA and TA in ascites for differen- tial diagnosis of malignant ascites.Methods:CEA mRNA,TA,CA19-9 and CEA were respectively detected in 105 cases malignant ascites and 103 cases benign ascites.Results:The positive rate of each index in malignant ascites were obviously higher than that in benign ascites(P<0.01).The sensitivity and accuracy of CEA mRNA and TA in diagnosis of malignant ascites were higher than CA19-9 and CEA.The diagnosis efficiency of combining CEA mRNA,TA and CA19-9 was the highest.Conclusions:The value of decting CEA mRNA and TA in diagnosis of malignant ascites were higher than CA19-9 and CEA,combined indexes can increase diagnosis efficiency.更多还原