【摘要】 目的检测血管内皮细胞生长因子(vascular endothelial growth factor,VEGF)和一氧化氮合酶2(nitric oxide synthase2,NOS2)在骨关节炎(OA)滑膜组织中的表达及相关性情况。方法回顾分析2003年1月—2004年9月我院骨科骨关节炎病理标本30例,女19例,男11例;对照组病理标本8例,男7例,女1例。应用免疫组化方法检测VEGF和NOS2在滑膜组织中的表达情况,并将结果用Spearman等级相关检验方法进行统计学分析。结果骨关节炎组NOS2和VEGF的阳性表达率分别为60%和86.7%,VEGF和NOS2表达间的相关性有高度统计学意义(rs=0.516,P<0.01)。结论VEGF和NOS2在骨关节炎滑膜组织中的表达有相关性,VEGF和NOS2的表达率较正常组织为高,VEGF和NOS2改变是OA发生、发展的重要介导因素。更多还原

【Abstract】 Objective To investigate the expression rate of of NOS2 and VEGF in the synovial membrane of osteoarthritis(OA)and study the relathionship between the two factors.Methods We retrospectively reviewed 30 patients who underwent osteoarthritis(case group)and 8 patients of control group from January 2003 to September 2004.Case group:male 11 cases,female 19 cases.Control group:male 7 cases,female 1 case.The synovial membrane of osteoarthritis was immunohistochemically detected with VEGF and NOS2,respectively.The results were analyzed with Spearman’s rank correlation.Results The expression rates of NOS2 and VEGF were 60% and 86.7%,respectively.The correlation coefficient between VEGF and NOS2 was statistically significant(rs=0.516,P<0.01).Conclusion The expression of VEGF and NOS2 in the synovial membrane of osteoorthritis was statistically significant.The expression rates of VEGF and NOS2 in osteoarthritis were higher than those in normal tissues.The two factors were associated with destructive process in OA.更多还原