【摘要】 目的:比较侵袭性牙周炎(AgP)患者和牙周健康者血浆白细胞介素-1β(IL-1β)和肿瘤坏死因子-α(TNF-α)的水平。方法:56例侵袭性牙周炎患者和39例牙周健康者空腹抽取静脉血。采用酶联免疫吸附方法测定血浆中IL-1β和TNF-α水平,比较两组的差异,并分析血浆IL-1β和TNF-α与各项牙周临床参数的相关性。结果:AgP患者血浆IL-1β的水平为7.23ng/L,显著高于健康对照者(3.52ng/L,P=0.003)。血浆IL-1β水平与出血指数、探诊深度、附着丧失、重度位点百分比有明显的正相关关系(相关系数r及P值分别为0.170,0.038;0.175,0.033;0.168,0.040;0.236,0.004)。AgP患者血浆TNF-α的水平(1.07ng/L)与牙周健康者(1.06ng/L)相比差异无统计学意义(P=0.437)。血浆TNF-α水平与各项牙周临床参数之间也均未发现相关关系(r=0.023,P=0.808;r=0.025,P=0.782;r=0.075,P=0.407;r=0.049,P=0.586)。结论:侵袭性牙周炎可能与血浆IL-1β水平的升高有关,未发现侵袭性牙周炎对血浆TNF-α水平的影响。更多还原

【Abstract】 Objective:To compare the levels of plasma IL-1β,TNF-α in aggressive periodontitis (AgP) patients and periodontally healthy subjects. Methods:Venous blood samples were collected from 56 AgP patients and 39 periodontally healthy controls. Clinical examination consisted of bleeding index (BI), probing depth(PD)attachment loss measurements (AL) and percentage of severe sites. Plasma levels of IL-1β and TNF-α were determined using a high-sensitivity ELISA assay. Results:The concentrations of IL-1β in AgP patients were significantly higher than those in healthy controls (7.23 ng/L vs 3.52 ng/L, P=0.003), which were positively correlated with BI, PD, AL and the percentage of severe sites (r=0.170, P=0.038; r=0.175, P=0.033; r=0.168, P=0.040; r=0.236, P=0.004). The difference between the levels of TNF-α in AgP patients and healthy controls was not observed (1.07 ng/L vs 1.06 ng/L, P=0.437). No correlations between the plasma level of TNF-α and the periodontal parameters were detected (r=0.023, P=0.808; r=0.025, P=0.782; r=0.075, P=0.407; r=0.049, P=0.586). Conclusion: AgP may have impact on the elevation of plasma level of IL-1β, while no association between AgP and plasma level of TNF-α was found.更多还原