【摘要】 目的:探讨血塞通对下肢缺血再灌注损伤的保护作用。方法:采用电子自旋共振技术和电子自旋共振捕集技术(N-tert-butyl-2-phenylnitrone,PBN)观察兔下肢缺血再灌注时出现PBN-自旋加合物信号。结果:该信号强度与缺血时间有关,缺血4h再灌注时的信号明显强于缺血2h再灌注;血塞通对该自旋加合物信号有明显猝熄作用。结论:血塞通对下肢缺血再灌注损伤具有一定的保护作用。更多还原

【Abstract】 Objective: To investigate the protective effect of Xuesaitong(total saponins of sanchi) on lower extremity ischemical reperfusion injury.Methods: To observe PBN-spin bulky adducts signal of lower extremity ischemical reperfusion of rabbit by using electron spin resonance technology and electron spin resonance promoter N-tert-butyl-2-phenylnitrone(PBN).Results: The signal intensity is correlated with time,compared with ischemia for 2 hours,the signal intensity of ischemia for 4 hours increased apparently.Xuesaitong would quench PBN-spin bulky adducts signal significantly.Conclusion: Xuesaitong have protective effect on lower extremity ischemia-reperfusion injury.更多还原