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脾边缘带淋巴瘤3例报告及文献复习

Three case reports of splenic marginal zone lymphoma and literature review

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【作者】 张雪晗李剑单渊东

【Author】 ZHANG Xue-han, LI Jian, SHAN Yuan-dong (Department of Medicine, Peking Union Medical College Hospital, Beijing 100730)

【机构】 中国医学科学院北京协和医院内科中国医学科学院北京协和医院内科 邮编100730邮编100730

【摘要】 目的总结脾边缘带淋巴瘤的临床特点、组织病理学特征、诊断、治疗方法及预后。方法回顾分析我院3例脾边缘带淋巴瘤患者的临床和随诊资料,并对相关文献进行复习。结果3例患者发病年龄49~71岁,从出现症状到明确诊断时间为3~11个月。3例发病时均有脾大,1例出现脾功能亢进造成的全血细胞减少,2例出现发热等B组症状,2例有结外受累。3例均为脾切除后经病理明确诊断,2例化疗后随诊仍为完全缓解,1例化疗结束后10个月复发。结论脾边缘带淋巴瘤是一种惰性的淋巴增殖性疾病,中位生存期长,65%~78%患者的诊断后生存期可超过5年,故明确诊断后可采用相对保守的治疗措施。

【Abstract】 Objective To investigate the clinical and histological characteristics, the diagnosis, treatment and prognosis of splenic marginal zone lymphoma. Methods Three cases of splenic marginal zone lymphoma were included and analyzed retrospectively. The related literature about splenic marginal zone lymphoma were reviewed. Results The age of three patients were from 49 to 71 years old. The interval between symptom appearance and diagnosis ranged from 3 to 11 months. All of the three cases have splenomegaly, but only one has cytopenias. Symptom B and involvement outside lymph nodes were both detected in two cases. The diagnosis of three cases were made after splenectomy. After chemical therapy, two cases were still in complete remission, but 1 case relapsed 10 months later. Conclusions Splenic marginal zone lymphoma is a low-grade lymphoma with an indolent clinical course and a long median survival time. About two thirds patients can survive more than 5 years after diagnosis. So relatively conservative therapy is appreciated.

  • 【文献出处】 北京医学 ,Beijing Medical Journal , 编辑部邮箱 ,2008年02期
  • 【分类号】R733.2
  • 【被引频次】3
  • 【下载频次】107
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