【摘要】 组蛋白修饰作为表观遗传中重要的调控机制之一,在包括基因表达调控等多种生物学过程中起着重要作用。组蛋白甲基转移酶和组蛋白去甲基化酶共同参与形成和维持不同的组蛋白甲基化状态,继而通过多种分子参与对组蛋白甲基化修饰的识别而引起下游过程的发生。本文拟从组蛋白甲基转移酶、组蛋白去甲基化酶等方面综述这一领域的研究进展。更多还原

【Abstract】 Histone modification as one of the key epigenetic regulation mechanisms plays critical roles in various biological processes,including regulation of chromatin structure dynamics and gene expression.Both histone methyltransferase and histone demethylases contribute to the establishment and maintenance of different histone methylation status.The ‘effectors’ which can recognize histone methylated sites build a relationship between these modifications and their down stream processes.This review summarized recent advances in histone methyltransferases and histone demethylases.更多还原