【摘要】 背景与目的:探讨Ras相似蛋白C(Ras homologue C,RhoC)和CD44剪接变异体v6(CD44splice variant V6,CD44v6)在胃癌中的表达及其与临床病理因素之间的关系。材料与方法:采用免疫组化SP法检测97例胃癌组织中RhoC和CD44v6的表达情况。结果:97例胃癌组织中RhoC和CD44v6阳性率分别为77.31%(75/97)、83.50%(81/97),两者表达存在相关性(P<0.05)。RhoC和CD44v6表达均与胃癌的浸润深度和肿瘤分期有关(P<0.05),且淋巴结转移组RhoC表达显著高于无淋巴结转移组(P<0.05)。结论:RhoC和CD44v6蛋白的过量表达是胃癌的发生发展中的频发事件,可以作为判断预后的指标之一。更多还原

【Abstract】 BACKGROUND AND AIM:To investigate the expressions of RhoC and CD44v6 proteins in gastric carcinoma(GC)and their relationship to clinicopathological factors.MATERIALS AND METHODS:Immunohistochemical staining SP method was used to evaluate the expressions of RhoC and CD44v6 in 97 cases of GC.RESULTS:75(77.31%)and 81(83.50%)of 97 cases showed overexpressions for RhoC and CD44v6,respectively.There was a significant correlation between the overexpression of RhoC and CD44v6(P<0.05).The expressions of RhoC and CD44v6 in GC were significantly associated with the depth of tumor invasion and TNM staging(P<0.05).Moreover,the RhoC overexpression was associated with lymph node metastasis(P<0.05).CONCLUSION:Overexpressions of RhoC and CD44v6 proteins are frequent events in GC.Measurement of these protein expressions might be used as a prognostic indicator for GC.更多还原