【摘要】 〗目的:探讨乙酰肝素酶(heparanase,HPA)、细胞黏附分子CD44v6在骨肉瘤组织中的表达及二者的相关性。方法:应用免疫组织化学染色的方法检测人骨肉瘤组织中HPA和CD44v6的表达。结果:HPA在骨肉瘤组织中表达阳性率为79.6%,CD44v6表达阳性率为55.1%,均显著高于骨软骨瘤中的20.0%和25.0%(P<0.05)。HPA表达与CD44v6表达呈显著正相关(r=0.663,P<0.001),两者表达与骨肉瘤临床分期、转移密切相关。结论:HPA和CD44v6在骨肉瘤组织中高表达可能促进肿瘤的黏附、侵袭和转移。更多还原

【Abstract】 Objective: To study the expression of heparanase and CD44v6 in osteosarcoma and analyze the correlation between them.Methods: The expressions of heparanase and CD44v6 in human osteosarcoma were detected by immunohistochemical staining.Results: The positive rates of heparanase and CD44v6 protein in osteosarcoma tissues were significantly higher in osteosarcoma tissues than in osteochondroma(79.6% vs 20.0% and 55.1% vs 25.0%,P<0.05).Expressions of heparanase and CD44v6 had positive correlation(r=0.663,P<0.001).Both of them were closely associated with clinical stage and metastasis of osteosarcoma.Conclusion: Overexpressions of heparanase and CD44v6 in human osteosarcoma may stimulate the adhesion,invasion,and metastasis of osteosarcoma.更多还原