【摘要】 目的:建立利舒康胶囊中盐酸小檗碱的高效液相色谱测定方法。方法:采用HYPERSILBDS C₁₈柱（150 mm×4.6 mm,10μm）;流动相:乙腈-0.1 mol·L^-1磷酸二氢钾-0.025 mol·L^-1十二烷基磺酸钠（50:25:25）。流速1.0 ml·min^-1;检测波长为345 nm。结果:平均回收率为98.9%,RSD为0.96%,方法重现性的RSD为1.33%（n=5）。盐酸小檗碱线性范围为0.194～0.972μg（r=0.9996）。结论:本法操作简便,结果准确,可用于利舒康胶囊的质量控制。更多还原

【Abstract】 Objective:To establish an HPLC method for determination of Berberine Hydrochloride in Lishukang capsules.Meth- od:HYPERSILBDS C₁₈column（150 mm×4.6 mm,10μm）was used,the mobile phase was acetonitrile-0.1 mol·L^-1potassium di- hydrogen phosphate-0.025 mol·L^-1sodium dodecylsulphate（50:25:25）with flow rate of 1.0 ml·min^-1.The UV detection wavelength was at 345 nm.Result:The average recovery was 98.9% RSD was 0.96%.The RSD of the repeatability test was 1.33%（n=5）. The limar range of berberine hydrochloride was 0.194-0.972μg（r=0.9996）.Conclusion:The method is simple and accurate and can be used for the quality control of Lishukang capsules更多还原