【摘要】 目的:观察新疆哈萨克族传统发酵乳酪的乳清（简称乳酪乳清）对实验性动脉粥样硬化大鼠内皮细胞损伤的保护作用。方法:通过灌胃高脂乳剂及注射大剂量维生素D₃致内皮损伤,建立动脉粥样硬化大鼠模型。高脂乳剂灌胃4周后给予乳酪乳清(25,50,100 mg·kg^-1)及阳性对照药辛伐他汀(20 mg·kg^-1),给药4周后,分别测定血脂、肝脂、C-反应蛋白（CRP）、内皮素（ET）、血栓烷B₂（TXB₂）、肿瘤坏死因子（TNF-α）和白细胞介素-8（IL- 8）等指标。结果:乳酪乳清3个剂量组均显著降低动脉粥样硬化大鼠血清总胆固醇、低密度脂蛋白胆固醇和三酰甘油以及肝脏匀浆中的TG含量（均为P<0.01）,均显著降低血清C反应蛋白水平（P<0.05）,并降低血浆ET和血清TNF-α及IL-8水平（P<0.05）。结论:乳酪乳清具有调节血脂及保护内皮细胞作用,提示其抗实验性动脉粥样硬化作用与内皮保护作用有关。更多还原

【Abstract】 Objective:To determine the effect of the fermented cheese whey,a kind of tradition- al Kazakh medicine,on experimental atherosclerotic formation in rats.Methods:Sixty rats were treated with intragastric high-fat diet and injection of high-dose of vitamin D₃ to induce injury of endothelial cells and atherosclerotic formation.From 4 weeks after above treatments,rats were randomly divided into 6 groups,and treated with fermented cheese whey (25,50,100 mg·kg^-1) or simvastatin (20 mg·kg^-1) for 4 weeks.Then,plasma lipids,hepatic lipids,and serum C-reaction protein （CRP）,endothelin （ET）,TXB₂,TNF-αand IL-8 were determined.Results:Compared with the atherosclerotic control, the total cholesterol,low density lipoprotein cholesterol and triglyceride in plasma,and IL-8,ET,TNF-αand CRP in serum were dose-dependently decreased in the fermented cheese whey groups.Conclu- sion:Fermented cheese whey,the traditional Kazakh medicine,has the antiatherogenic effect similar to simvastatin.更多还原