【摘要】 目的:比较注射用灯盏花素对比格（Beagle）犬和食蟹猴的体内毒性。方法:普通级Beagle犬32只,雌雄各半,设生理氯化钠溶液（NS）对照和注射用灯盏花素40,80,120 mg·kg^-1剂量组。食蟹猴4只,设NS对照和注射用灯盏花素200 mg·kg^-1组。2种动物均静脉滴注给药13周,停药恢复4周,观察体内毒性。结果:Beagle犬80和120 mg·kg^-1组出现呕吐、腹泻、流涎等不良反应。120 mg·kg^-1组有1只动物给药11d皮肤出现斑疹、荨麻疹;给药第11周有1只动物出现呕血、便血后死亡。食蟹猴200 mg·kg^-1组仅发现1只动物出现间断性流涎。Bea- gle犬和食蟹猴各剂量组体重增长,进食量正常,血液、生化等其他各项检测指标未见明显异常。结论:食蟹猴和Beagle犬对注射用灯盏花素的耐受性、敏感性和毒性反应均存在种属差异。更多还原

【Abstract】 Objective:The toxicities of intravenous breviscapine were compared in Beagle dogs and monkeys.Methods:In 32 Beagle dogs and 4 monkeys of either sex,breviscapine (at 40,80 and 120 mg·kg^-1 in dogs;200 mg·kg^-1 in monkeys) was intravenously dripped once daily for 13 weeks,and then recovered for 4 weeks.The toxic responses were observed.Results:In some Beagle dogs treated with 80 and 120 mg·kg^-1·d^-1,vomiting,diarrhea and salivation were observed.At 11th day,one dog with 120 mg·kg^-1·d^-1 showed macular rash and urticaria;one dog with 120 mg·kg^-1·d^-1 died of he- matemesis and hematochezia.Only one monkey with 200 mg·kg^-1·d^-1 showed an intermittent sialorrhea. The body weight,food consumption,hematological and biochemical variables in breviscapine groups were not different from those in control dogs and monkeys.Conclusion:The tolerance,sensitivity and toxicity of breviscapine were obviously different between Beagle dogs and monkeys.更多还原