【摘要】 目的:观察抗精神病药慢性给药对大鼠海马内neuregulin 1（神经调节蛋白1,NRG1）与ErbB4蛋白表达的影响。方法:16只Wistar大鼠随机分为4组,分别腹腔注射生理氯化钠溶液、氟哌啶醇(1 mg·kg^-1)、氯氮平(10 mg·kg^-1)和利培酮(1 mg·kg^-1),qd,连续给药4周。以免疫组织化学方法检测NRG1与ErbB4在海马CA1,CA3和齿状回区的表达。结果:与对照组比较,慢性给予氟哌啶醇、氯氮平或利培酮均显著上调了海马CA3区NRG1与ErbB4的表达。氯氮平还上调了齿状回区NRG1的表达。结论:抗精神病药慢性给药增加大鼠海马NRG1与ErbB4的表达,这种改变可能与抗精神病药治疗效应有关。更多还原

【Abstract】 Objective:To determine the expression of neuregulin 1 （NRG1） and ErbB4 in rat hippocampus following chronic antipsychotic drug administration.Methods:Sixteen Wistar rats were ran- domly divided into 4 groups,and received intraperitoneal injections of saline （control）,haloperidol (1 mg·kg^-1),clozapine (10 mg·kg^-1) or risperidone (1 mg·kg^-1) once daily for 4 weeks.Immunoreac- tivity of NRG1 and ErbB4 in the hippocampal CA1,CA3 and dentate gyrus subregions was determined by immunohistochemistry.Results:Compared to saline control,chronic administration of haloperidol,cloz- apine or risperidone significantly upregulated the expression of NRG1 and ErbB4 in the hippocampus. Conclusion:Chronic antipsychotic drug administration increases the expression of NRG1 and ErbB4 in rat hippocampus,which may correlate with their therapeutic effects.更多还原