【摘要】 目的评价雷公藤治疗银屑病的疗效。方法按文内纳入标准和排除标准计算机检索Medline、Pubmed(1966-2004)、Ovid、The Cochrane library2004.4th、中国生物医学文献数据库(1978-2004)、Vip全文数据库(1994-2004)、解放军医学图书馆、国家科技图书文献中心的数据库,手工检索国内的期刊杂志和药厂提供的资料。应用RevMan4.2版软件进行统计分析。结果9个雷公藤治疗银屑病的有效率研究按亚组分类后,组间有异质性(χ2=22.84,P=0.004,I2=65.0%),用随机效应模型进行合并,结果显示应用雷公藤治疗银屑病的有效率与对照组差异有统计学意义[OR4.38,95%CI(2.45,7.81)]。结论由于目前缺乏高质量的研究,故尚不能据此证实雷公藤治疗银屑病是有效的,随着高质量的报告出现,今后可以不断地完善本评价。更多还原

【Abstract】 Objective To evaluate the effiency of Tripterygium wilfordii on treating psoriasis. Methods This systematic review for this studies are the randomized or quasi-randomized controlled trials of Tripterygium wilfordii in patients with psoriasis from The Cochrane library 2004. 4th,China BioMedical Literature on disc(CBMdsic),National Science and Technology Library(nstl),Vip,and some Chinese journals. Methodological quality assessment and data extraction assessment for methodological quality was using a modification of criterriagive in the Cochrane Reviewers’ Handbook and the criteria of Jadad. RevMan 4.2 was used for meta-analysis. Results The differences between Tripterygium wilfordii group and controlled group have statistics significance (OR=4.38,95%CI 2.45-7.81). Conclusion Tripterygium wilfordii is not likely to be an effective treatment for psoriasis. It is hoped that this review could highlight the inadequacy of psoriasis in general and encourage improvements in methodological quality and standards of reporting.更多还原