【摘要】 目的:探讨湿热型慢性乙型肝炎(CHB)患者血清TGF-β1、TIMP-1的水平。方法:选择HBeAg阳性CHB患者63例进行观察,其中,湿热型27例,非湿热型36例。同时,选择健康人16例为对照组。血清TGF-β1检测采用ELISA法、血清TIMP-1检测采用单克隆抗体透射比浊法。结果:63例CHB患者血清TGF-β1、TIMP-1水平分别为(98.22±23.52)μg/L、(122.67±26.06)μg/L,与对照组比较差异均有非常显著性意义(P<0.01)。湿热型CHB患者血清TGF-β1水平及TIMP-1水平均明显升高,与非湿热型患者相比差异有非常显著性意义(P<0.01)。结论:湿热型CHB患者血清TGF-β1、TIMP-1水平明显升高,预示肝纤维化进程已经启动,中医论治肝纤维化不可忽视湿热为患的影响。更多还原

【Abstract】 Objective:To study on the serum levels of TGF-β1 and TIMP-1 in paients with chronic hepatitis B(CHB)in TCM types damp-heat.Methods:Sixty-three paients with CHB were selected and divided into damp-heat group(27 cases)and non damp heat-group(36 cases).In the meantime,16 cases of healthy staff were selected as the normal group.The level of TGF--β1 in serum were detected by the methods ELISA and the level of TIMP-1 in serum were detected by the methods ITA.Results:The serum levels of TGF-β1 and TIMP-1 in paients with CHB were much higher than that in the normal group(P<0.01).The serum levels of TGF-β1 and TIMP-1 in paients with CHB in damp-heat type were much higher than that in the non damp-heat group(P<0.01).Conclusion:The serum levels of TGF-β1 and TIMP-1 in paients with CHB in damp-heat type are very high,which indicate the process of hepatic fibrosis has been started.Therefore,we must pay more attention to the factor of damp-heat in the hepatic fibrosis treated by TCM.更多还原