【摘要】 目的了解永靖县先天性缺陷的发生情况并探讨其影响因素。方法对永靖县全县(19个乡镇)进行普查,从计划生育技术服务站、医院、妇幼保健站等机构及入户调查获取2003年、2004年出生儿(包括引产、死胎和死产儿)及其父母的情况,进行病例对照分析。结果收回有效问卷2 793份,先天性缺陷74例,发生率为26.49‰,其中活产儿57例,出生缺陷发生率为20.41‰;对先天性缺陷的相关因素运用单因素分析进行初步筛选,再将筛选的因素引入多因素非条件Logistic回归分析模型,得到先天性缺陷的主要影响因素为胎位异常、孕母镇静止吐药服用史、抗生素服用史、父母血缘关系。结论永靖县出生缺陷发生率与甘肃省和全国平均水平的差异无统计学意义;先天性缺陷的影响因素具有多元性。应继续加强孕期宣教,使育龄妇女了解孕期可能出现的并发症及其危害性,减少有生理缺陷儿的出生,提高人口素质。更多还原

【Abstract】 Objective To study the incidence of congenital malformation of Yongjing county and explore the suspected factors. Methods Based on census data of children born in 2003 and 2004 cincluding induced labors,stillbirth and perinata death and their parents collected from family planning technical service stations,hospitals and maternity child care centers of 19 town ships in Yongjing county,a case-contol study was conducted.Results A total of 2 793 valid questionnaires were returned,of which 74 cases were congenital malformation(the rate was 26.49‰),with 57 cases of live births(the rate of birth defect was 20.41‰).Factors were screened initially with single-factor analysis,and then introduced into multi-factor screening non-conditional logistic regression analysis model to find out the main factors for congenital malformation.The results indicated that abnormal fetal position,sedatire antiemetic use during pregrancy,the history of antibiotic use and parents’ blood relationships were the main influencing factors of congenital malformation.Conclusion The incidence of birth defects in Yongjing County was not statistically significant different with that of Gansu Province and the national average level.Congenital malformation was caused by multiple factors.In order to reduce infants born with birth defects and improve the quality of population,education during pregnancy should be further strenghtened to help the women of childbearing age understand complications and dangers that may occur during pregnancy.更多还原