【摘要】 利用电喷雾电离技术对葛根素的结构和质谱裂解规律进行研究,用Mass frontier3.0软件辅助解析了主要特征碎片离子及其裂解途径。结果发现,葛根素主要通过D环的糖苷碎裂而发生裂解,出现碎片m/z399、381、363、351、335、321。碎片m/z399裂解成碎片m/z381,碎片m/z381又裂解成碎片m/z363和351为ESI-MS裂解特征。更多还原

【Abstract】 Structure and MS/MS fragment pathway of pueratin were elucidated with electron spray ionization mass spectrometry.The characteristic ions and fragment mechanism were explained by Mass Frontier 3.0. Pueratin mainly fragmented on the glycoside of D ring.The characteristic ions of pueratin were m/z 399、381、363、351、335、321 and m/z 399 fragment to m/z 381, ion m/z 381 fragment to m/z 363 and m/z 351. The result provides important information for the drug metabolism and structural modification research of puerarin.更多还原