【摘要】 目的探讨北京城市居民血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)与脑卒中发病的关系。方法1987年在北京市崇文和西城区各选取含10000人口的社区,对35岁以上的人群随机抽取3601人进行基线调查,包括血清TC、TG、HDL-C以及其他危险因素。此后,对该基线人群脑卒中发病情况进行了为期10a的随访观察。结果共随访到2466人,脑卒中发病212例,其中缺血性卒中146例,出血性卒中62例,未分类4例。单因素分析显示,TC和TG是缺血性卒中的危险因素,HDL-C是总卒中和缺血性卒中的保护因素;多因素分析显示,仅HDL-C是总卒中和缺血性卒中的保护因素。结论HDL-C是脑卒中的保护因素,TC和TG不是脑卒中的独立危险因素。更多还原

【Abstract】 Objective To explore the relationship of stroke with total cholesterol,triglycerides and high density lipoprotein in the city dwellers of Beijing. Methods In 1987,3 601 people were randomly selected from two communities including more than 100 000 people in Chongwen and Xicheng districts of Beijing,and were examined on their baseline of TC,TG,HDL-C and other risk factors; then,followed forward in 10 yrs for stroke incidence. Results 2 466 people were completely followed up,and stroke occurred in 212 people,including 146 cases of ischemic stroke,62 hemorrhagic stroke and 4 undetermined. Single factor analysis showed that serum TC and TG was risk factors for total stroke,HDL-C was protective factor for both total and ischemic stroke; but multiple factor analysis showed that only HDL-C was the protective factor for total stroke and ischemic stroke. Conclusions HDL-C is the protective factor for stroke,but TC and TG are not the independent risk factors for stroke.更多还原