【摘要】 目的观察 ESHAP 方案作为解救化疗方案治疗复发或难治性侵袭性非霍奇金淋巴瘤(NHL)的疗效和安全性。方法选取38例复发或难治性侵袭性 NHL 患者,使用 ESHAP 方案(依托泊苷、甲泼尼龙、顺铂、阿糖胞苷)作为解救方案进行化疗。结果 38例患者各接受了2～6个周期 ESHAP方案化疗,总的客观有效率为55.3%,完全缓解率26.3%;主要不良反应为骨髓抑制伴感染,均可耐受。结论 ESHAP 方案是治疗复发或难治性侵袭性 NHL 安全有效的解救方案之一。更多还原

【Abstract】 Objective To evaluate the efficacy and safety of ESHAP regimen,as a salvage regimen, in treating patients with relapsed or refractory aggressive NHL.Methods 38 patients with relapsed or refrac- tory aggressive NHL were selected to be treated by ESHAP regimen.Results The 38 patients received ES- HAP regimen with a range of 2～6 cycles. The total RR was 55.3 % with complete response(CR)rate of 26.3 %.The major toxicity was myelosuppression with infection,which was tolerable.Conclusion ESHAP regimen is one of safe and effective salvage regimens for the patients with relapsed or refractory aggressive NHL.更多还原