【摘要】 目的探讨大鼠视神经夹伤后视网膜病变的时序性变化。方法建立大鼠视神经夹伤模型。分别于伤后1、3、7、15、30 d光镜下计数视网膜神经节细胞(RGC8)数目的变化。结果大鼠视神经夹伤诱导RGCs较正常眼明显减少。结论应用40 g力视神经夹建立的定量视神经损伤动物模型是可行的.并可应用于视神经损伤修复的研究中。更多还原

【Abstract】 Objective To observe the morphological change of retina after optic nerve crush in adult rats. Methods The models of optic nerve crush in rats were made.The change of retinas in different time(1,3,7,15, 30d respectively)after injury were observed by light microscope.Results The number of retinal ganglion cells (RGCs)was significantly reduced in the partial lesion of optic nerve crush compared with normal optic nerves with- out injury.Conclusion A pair of cross-action forceps with pressure of 40g used to clip rat optic nerves to create ONI animal model was possible,and could be used in ONI recovery response.更多还原