【摘要】 目的探讨甲氨喋呤(MTX)联合米非司酮(Ru486)及单用MTX注射保守治疗异位妊娠的疗效比较。方法对256例患者行血绒毛促性腺激素(8-HCG)测定和B超检查,确诊异位妊娠后,应用随机分类法分为两组,A组119例采用MTX 50 mg/m~2单次肌注并加服Ru486 150 mg,MTX剂量≤80 mg/次;B组137例单用MTX治疗。用药5 d后两组若血β-HCG下降<15%,可再次用药。结果A组成功率88.23% (105/119),B组86.13%(118/137),两组比较差异无统计学意义(P>0.05)。第1个疗程成功率,A组71.42%(85/119),B组56.20%(77/137),两组比较差异有统计学意义(P<0.05)。MTX剂量:A组平均93.33 mg,B组113.37 mg,两组比较差异有统计学意义(P<0.05)。平均住院日:A组(9.1±3.6)d,B组(13.48±5.2)d,两组比较差异有统计学意义(P<0.01)。结论MTX与Ru486联合治疗异位妊娠效果确切,剂量小,疗程短,不良反应较微,是一种较理想的治疗方法。更多还原

【Abstract】 Objective To discuss the effect of ectopic pregnancy between methotrexate(MTX)with mifepri- stone(Ru486)and single MTX injection.Methods 256 patients with confirmed ectopic pregnancy were randomly divided into group A and group B.Group A was treated by single MTX(50mg/m~2)injection and Ru486(≤80mg), group B by single MTX injection.Five days after treatment,if Beta-HCG of woman in both groups decreased less than 15 %,the treatment would continue.Results The successful rate of the therapy of group A was 88.23 %(105/ 119)and that of group B was 86.13%(118/137)(P>0.05)and no significant statistical difference was found.But the successful rate of first therapy of group A was 71.42%(85/119)and group B was 56.20%(77/137)(P<0.05),mean MTX dose of group A was 93.33mg and group B was 113.37rag(P<0.05),mean in-hospital days of group A were(9.1±3.6)and group B were(13.48±5.2)(P<0.01).There was significant difference between the two groups.Conclusion MTX combined with Ru486 was an effective and safe therapy in conservative treat- ment of ectopic pregnancy,whose side effect was small.It shortened the in-hospital days,and was a comparatively ideal therapy.更多还原