【摘要】 目的了解帕金森病患者轻度认知损害(MCI)的事件相关电位(ERP)的敏感电生理指标及其临床价值和特点。方法对36例非痴呆帕金林病患者(A 组)和30例健康受试者(B 组)进行简易智能状态量表(MMSE)、临床记忆量表测定并同时完成听觉经典 Oddball 序列的事件相关电位检查。结果 A 组的临床记忆量表测定 MQ 值较 B 组明显降低,A 组67.8%有短时记忆(STM)障碍,B 组8%存在 STM 障碍。A 组P300潜伏期(PL)与 B 组比较差异无统计学意义(P>0.05)。A 组的P300和失匹配负波(MMN)的波幅较 B组降低,MMN 的潜伏期明显延长,与 B 组比较差异有统计学意义(P<0.05)。临床记忆量表测定说明记忆商(MQ)与上述检查呈正相关(r=0.658,P<0.05)。结论事件相关电位的成分 P300及 MMN 对非痴呆帕金森患者早期轻度认知损害的诊断有重要的临床价值,MMN 比 P300、MMSE 更敏感,尤其对观察不能完成神经心理测试的帕金森患者的认知功能有重要的特异性的临床价值。更多还原

【Abstract】 Objective To understand the indexes to the sensitive electrophysiology,clinical value and features of the event-related potential(ERP) about mild cognition impairment (MCI) in patients with Parkinson’s disease. Methods 36 patients with non-demented Parkinson’s disease(ND-PD,group A) and 30 volunteers(group B) were examined with tests of the mini-mentality state examination(MMSE),clinical memory scale and ERP evoked by the classical auditory Oddball Paradigms.Results The memory quoteint (MQ) value of the clinical memory scale of group A was significantly lower than that of group B.67.8 percent of group A had short-term memory(STM) dis- turbance.8 percent of group B had STM disturbance.There was no remarkable difference of P300 potential latency (PL) between group A and group B(P>0.05).P300 and amplitudes of the mismatch negativity(MMN) of group A were lower than that of group B.PL of MMN was obviously prolonged.By comparing PL of group A with thar of group B,there was obvious difference(P<0.05).Tests of the clinical memory scale showed that there was positive correlation between MQ and the above tests(OR=0.947,P<0.05).Conclusion The component P300 of ERP and MMN have an improtant clinical value in diagnosis of earlier MCI for patients with ND-PD.MMN is more sensi- tive than P300 and MMSE,and there is a specific clinical value especially for patients with Parkinson’s disease via neuropsyehological tests of cognitive functions that cannot be observed.更多还原