【摘要】 目的探讨髓母细胞瘤临床与预后的相关因素。方法回顾性分析经手术后病理学证实的73例髓母细胞瘤患者的肿瘤部位、肿瘤切除率、脑干侵袭程度、放疗、化疗、分流手术、胶质分化等相关因素对其预后的影响。73例患者中男48例,女25例,年龄平均13.6岁。并对55例患者进行了随访。结果在获取随访的55例患者中手术死亡6例,余49例平均生存时间为61个月,术后3年仍存活者20例,3年生存率为63.98%;术后5年仍存活者8例,5年生存率为43%,全脑-后颅-脊髓放疗患者较仅做全脑一后颅放疗的患者预后好。结论髓母细胞瘤患者的预后日前仍较差,手术切除后正规放疗及化疗有助于提高预后。更多还原

【Abstract】 Objective To analyze the correlation between the prognosis of medulloblastoma (MB) and relevant clinical factors.Methods Seventy-three MB patients,48 males and 25 females,aged 13.6 (2～40),underwent surgical treatment and part of them underwent radiotherapy and/or chemotherapy. Follow-up was conducted among 55 cases for 40.0 months (2 months～8 years and 5 months).The correlation between the prognosis and the clinical factors,such and sex,age,tumor location,extent of tumor resection,brainstem invasion,radiotherapy,chemotherapy,ventriculoperitoneal shunt and glial differentiation was analyzed.Results Six patients died postoperatively,and average survival time of the other 49 patients was 61 months.Twenty patients had a survival time of 3 years after operation,and the 3-year survival rate was 63.98%;and 8 patients survived for 5 years after operation with a 5-year survival rate of 43%.The prognosis Analysis showed that only radiotherapy was the only influencing factor of survival time. Those undergoing whole brain/posterior fossa plus spinal axis radiotherapy showed a better prognosis than those undergoing whole brain/posterior fossa radiotherapy.Conclusion The prognosis of MB is not good; yet,surgical resection with regular radiotherapy and chemotherapy is helpful for the prognosis of MB.更多还原