【摘要】 目的探讨脑膜瘤细胞增殖能力、肿瘤复发与血管内皮生长因子(VEGF)蛋白表达之间的关系。方法应用免疫组织化学方法检测36例复发脑膜瘤及30例原发脑膜瘤标本的VEGF和增殖细胞核抗原(PCNA)表达。结果复发脑膜瘤VEGF蛋白阳性表达率89%(32/36)明显高于原发脑膜瘤43%(13/30)(x~2=25.59,P<0.01)。复发脑膜瘤PCNA指数(65.72±9.22)高于原发脑膜瘤(20.81±7.43,P<0.05)。VEGF蛋白表达强阳性、弱阳性及阴性者的PENA指数分别为78.64±10.02、49.45±8.31、6.23±1.45,差异有统计学意义(P<0.01)。结论VEGF蛋白的表达水平与脑膜瘤的复发和增殖能力有关,VEGF蛋白表达水平可能是脑膜瘤复发的预测指标之一。更多还原

【Abstract】 Objective To study the correlation of vascular endothelial growth factor (VEGF) ex- pression with meningioma recurrence and proliferation activity of the tumor cells.Methods The expres- sion of VEGF and PCNA in 36 recurrent and 30 primary meningiomas was detected by immunohistochemis- try.Results The positive rate of VEGF expression in recurrent meningioma (89%,32/36) was higher than that in primary meningioma (43%,13/30,x~2=25.59,P<0.01).The PCNA index of recurrent men- ingioma (65.72±9.22) was significantly higher than that of primary meningioma (20.81±7.43,P<0.05).The PCNA index of meningioma with VEGF strong positive-expression,lower positive-expression and negative-expression was 78.64±10.02,49.45±8.31 and 6.23±1.45 respectively,and the differ- ence was significant (P<0.01 ).Conclusion The expression level of VEGF is correlated with meningio- ma recurrence and proliferation activity of the tumor cells,and VEGF expression may be a predictive mark- er for detecting the recurrence of meningioma.更多还原