【摘要】 目的观察不同冲洗液对预防脊柱后路内固定术后早期感染的预防作用。方法将48只家兔分成4组,试验组动物于后路置入两根"["形的克氏针,在其周围加入1×10~8 cfu/ml浓度的金黄色葡萄球菌菌液200μl。对照组伤口不予冲洗。生理盐水冲洗组、活力碘冲洗组和庆大霉素生理盐水冲洗组则于加入菌液3 min后分别用生理盐水、0.10%活力碘和庆大霉素生理盐水(24万U/500 ml)各200 ml冲洗创面5 min。术后2周通过观察局部皮肤表现、渗出物性状和细菌培养来判断是否发生感染。结果对照组、生理盐水冲洗组和活力碘冲洗组感染率均>90%。庆大霉素生理盐水冲洗组感染率为9.2%,明显低于对照和其他各组(P<0.01)。结论庆大霉素生理盐水冲洗创面可显著降低脊柱内固定术后金黄色葡萄球菌污染的感染率,感染率仍较高,敏感抗生素的应用是有必要的。更多还原

【Abstract】 Objective To evaluate the preventive effects of intraoperative irrigation with different solutions on postoperative early infection after spine internal fixation.Methods Forty-eight rabbits were divided into 4 groups and two"["type Kirsehner’s wires were implanted into two pedicles and followed by the instillation of 200μl stap-hylococcus aureus suspension of 1×10~8 cfu/ml into the wound.In the control group,the wound was closed after the implantation and instillation.In the saline group,povidone io- dine group and gentamycine saline group 200 ml solution of saline,0.10% povidone iodine and gentamy- cine saline(0.48 g/L)were irrigated respectively for 5 min.Two weeks after operation,the wounds were assessed by observing the local appearance of skin,the character of the effusion and by bacterial culture. Results The incidence of infection in the control group and in the groups irrigated respectively with sa- line solution and 0.1% povidone iodine solution was over 90%.And in the group irrigated with gentamy- cine saline solution,the incidence was 9.2%(P<0.01).Conclusion Intraoperative irrigation with gen- tamycine saline solution can significantly reduce the incidence of infection in the situation of wound con- tamination by staphylococcus aureus in the wound of spine internal fixation,but the incidence of infection was also high and sensitive antibiotics were necessary.更多还原