【摘要】 目的探讨抗 C 反应蛋白单体(mCRP)抗体在系统性红斑狼疮(SLE)中的意义。方法以天然的 mCRP 为抗原,用 ELISA 的方法检测113例 SLE 患者、疾病对照组(65例,包括类风湿关节炎、原发性干燥综合征、骨关节炎、强直性脊柱炎、系统性硬化症、混合结缔组织病)和正常对照组(32例)血清抗 mCRP 抗体水平,同时检测 SLE 患者血清 CRP 水平,记录其各种临床表现及实验室指标,分析抗 mCRP 抗体与 CRP 水平及疾病活动性的关系。结果 SLE 患者的抗 mCRP 抗体水平显著高于疾病对照组和正常对照组(t=2.502,5.352,P 均<0.05)。抗 mCRP 抗体阳性的 SLE 患者的红细胞沉降率(ESR)较抗 mCRP 抗体阴性患者明显增快(t=2.869,P<0.01),但两者的外周血 CRP 水平相似(H=-0.432,P>0.05)。SLE 患者抗 mCRP 抗体水平与 SLE 疾病活动指数的高低及血清 IgG水平的高低呈明显的正相关(r=0.248,0.392,P 均<0.01),与合并感染无明显相关性(t=0.658,P>0.05)。结论 SLE 患者血清抗 mCRP 抗体水平明显增高,并与患者的 SLE 疾病活动指数的高低呈明显的正相关;抗 mCRP 抗体可作为判断 SLE 疾病活动性的指标之一。更多还原

【Abstract】 Objective To study clinical significance of anti-momoner C-reactive protein (anti- mCRP) antibody in systemic lupus erythematosus (SLE) and assess the relationship between serum CRP and anti-mCRP antibody.Methods Enzyme-linked immunosorbent assay (ELISA) was applied to determine serum level of anti-mCRP antibody in 113 pateints with SLE,65 patients with other rheumatic diseases,including primary Sjgren syndrome,rheumatoid arthritis,osteoarthritis,ankylosing spondylitis and systemic sclerosis,and 32 healthy controls.Serum level of CRP was evaluated by turbidimetry.Clinical manifestations and laboratory indicators of the patients were all recorded.Results Serum level of anti- mCRP antibody in SLE patients was significantly higher than that in patients with other rheumatic diseases and healthy controls,respectively (t=2.502 and 5.352,respectively,P<0.05).Erythrocyte sedimentation rate (ESR) in SLE patients with positive anti-mCRP antibody was significantly faster than that in those with negative one (t=2.869,P<0.01),but they had similar CPR level (H=-0.432,P> 0.05).Titer of anti-mCRP antibody closely correlated with systemic lupus erythematosus disease activity index score (r=0.248,P<0.01),but did not correlate to infection complications (t=0.658,P>0.05). Conclusions Level of Anti-mCRP antibody increased significantly in patients with SLE,which associated with disease activity of SLE and can be used as a valuable marker in evaluating activity of SLE.更多还原