【摘要】 目的了解南京地区1999-2006年淋球菌对环丙沙星的耐药现状。方法对1999-2006年在南京地区性病门诊患者中分离到的1208株淋球菌,采用琼脂稀释法测定环丙沙星的最小抑菌浓度(MIC)。结果对环丙沙星耐药(MIC 1 mg/L)的淋球菌率由1999年的83.93%(94/112)上升至2006年的98.99%(196/198),平均总耐药率为96.61%(1167/1208)。其中环丙沙星高度耐药(MIC≥4 mg/L)的淋球菌比率达71.61%(865/1208)。结论南京地区流行的淋球菌对环丙沙星的耐药情况极其严重。更多还原

【Abstract】 Objective To study ciprofloxacin resistance in Neisseria gonorrhoeae isolates in Nanjing City from 1999 to 2006.Methods Minimum inhibitory concentration(MIC)of ciprofloxacin was deter- mined by agar dilution method in 1208 strains of N.gonorrhoeae isolated from outpatients in a STD clinic in Nanjing City.Results The prevalence of ciprofloxacin resistance increased from 83.93% in 1999 to 98.99% in 2006.Among these strains,71.61%(865/1208)were highly resistant(MIC≥4 mg/L)to ciprofloxacin.Conclusion In Nanjing City,ciprofloxacin resistance of N.gonorrhoeae is a significant public health issue.更多还原