【摘要】 目的检测尖锐湿疣患者外周血CD8~+T细胞白介素-2、白介素-12、干扰素-γ、白介素-4的表达水平,探讨其在尖锐湿疣发病中的作用。方法应用流式细胞仪检测60例尖锐湿疣患者和20例正常人对照者外周血CD8~+T细胞白介素-2、白介素-12、干扰素-γ、白介素-4的表达水平。结果尖锐湿疣患者外周血CD8~+T细胞白介素-2、白介素-12、干扰素-γ阳性细胞百分比均显著下降(P<0.01);白介素-4~+CD8~+T细胞百分比与正常人对照组比较,差异无统计学意义(P>0.05);干扰素-γ~+/白介素-4~+T细胞比值显著低于正常人对照组(P<0.01)。结论尖锐湿疣患者Tc1细胞水平低下,Tc1/Tc2显著低于正常人对照。更多还原

【Abstract】 Objective To detect the levels of cytokine IL-2,IL-12,IFN-γand IL-4 secreted by peripheral CD8~+ T lymphocytes in patients with condyloma acuminatum (CA).Methods Flow cytometry was employed to study the expression of cytokines IL-2,-12,INF-γand IL-4 in CD8~+ T lymphocytes in the peripheral blood of 60 patients with CA and 20 healthy controls.Results The percentage of CD8~+ T lym- phocytes producing IL-2,IL-12 and IFN-γwere significantly lower in CA patients than that in healthy con- trols (P<0.001),while the percentage of IL-4-producing CD8~+ T lymphocytes was of no significant differ- ence between two groups.The ratio of Tc1/Tc2 was also decreased in CA patients as compared with the healthy controls (P<0.001).Conclusion The quantity of Tc1 cells and the ratio of Tc1/Tc2 are signifi- cantly lower in CA patients than those in healthy controls.更多还原