【摘要】 2-甲基-4-硝基-1H-咪唑经乙酸氯甲酯保护咪唑环上的1位N得1-乙酰氧甲基-2-甲基-4-硝基咪唑(3),继而和手性环丙硫酸酯反应,再经水解得R型-或S型-塞克硝唑,总收率均约38%(以3计)。更多还原

【Abstract】 The stereoisomers of secnidazole were synthesized from 2-methyl-4-nitro-1H-imidazole by protection with chloromethyl acetate to give 1-acetoxymethyl-2-methyl-4-nitroimidazole(3), which was reacted with chiral cyclic sulfate followed by hydrolysis with overall yields of about 38%(based on compound 3).更多还原