【摘要】 目的探讨老年期抑郁症认知功能障碍的检测方法,分析其临床意义。方法采用配对研究法,分别使用听觉诱发电位P300(AEP-P300)和老年认知功能量表(SECF)对42例老年期抑郁症患者(观察组)及42名正常老年人(对照组)进行检测。结果SECF检测发现,观察组识记、广度、回忆1、回忆2、分类和总分等项目分值明显低于对照组,差异有统计学意义(P<0.05或P<0.01);P300检测发现,观察组P3潜伏期及反应时间明显延长(P<0.05及P<0.01),波幅明显降低(P<0.05),且P3潜伏期延长与病期、SECF总分呈负相关关系(r=-0.607,P<0.01);以P3潜伏期延长2个标准差为标准,P300异常率诊断与SECF检测的一致率为86.67%。结论老年期抑郁症患者的认知功能损害以注意、记忆功能障碍为主,SECF检测较为敏感,适合用于临床筛查,P300与SECF检测一致性好,是一种可靠的实验室检测方法。更多还原

【Abstract】 Objective To explore the detection methods for cognitive dysfunction of the major depression in Elderly and analyze their clinical significance.Methods Using matched-pairs study,42 patients with seniie de- pressive disorders(experimental group)and 42 normal aged people(control group)were examined with auditory e- voked potential P300(event related potential,ERP-P300)and SECF,respectively.Results It was found that the scores with registration,span,recall,classification and total score of the subjects in the experimental group were sig- nificantly lower than those in the control group(P<0.05 or 0.01);the P3 lateney and reaction time as revealed with P300 examination were significantly lengthened(P<0.05 or 0.01),and the amplitude of P300 was significantly lower(P<0.05).It was also found that the prolongation of P3 latency and the reduction of the SECF total score were negatively related to the period of onset(r=-0.607 ,P<0.01).Taking 2 standard deviations of lengthening of P3 latency as standard,the abnormal rate of P300 was 86.67% which was basically consistent with the diagnosis of the SECF.Conclusion Cognitive dysfunctions of senile depressive patients were mainly attention and memory dis- orders,the SECF detections were more sensitive and suitable for clinical screening,and the P300 was very consistent with the SECF and a reliable laboratorv detection method.更多还原