【摘要】 目的研究高压氧治疗能否改善链脲佐菌素(STZ)大鼠糖尿病性心肌的病损程度。方法STZ大鼠造模成功3个月、电镜证实有心肌病变后,随机分为3组:①高压氧治疗组60只:每天接受0.15 MPa高压氧治疗1 h,连续20 d;⑦糖尿病对照组64只:不做治疗;③正常对照组40只:腹腔注射生理盐水的无糖尿病正常大鼠。分别在疗程的5、10、20 d后处死治疗组及同期对照组大鼠,取心脏组织进行HE染色病理学观察和电镜观察。结果高压氧治疗20 d后STZ大鼠的糖尿病性心肌病变明显好于同期糖尿病对照组,电镜观察显示肌丝排列整齐、线粒体排列规则、结构紧凑。结论高压氧治疗可减轻STZ大鼠糖尿病性心肌组织的病损程度。更多还原

【Abstract】 Objective To investigate whether hyperbaric oxygen therapy(HBOT)could improve diabetic caniiomyopathy in streptozotoxin(STZ)-induced diabetic rats.Methods STZ-induced diabetes was induced in 62 SD rats.Diabetic cardiomyopathy was showed by electric micrographs.Then they was randomly divided into three groups.The HBOT group(n=60)was treated with HBO(0.15 Mpa for 1d)for 20 days.The diabetic control group (n=64)was treated by only insulin.The normal control group(n=40)did not undertake any treatment.Rats in three groups were sacrificed at 5 d,10 d and 20 d seperatilely.The Morphological analyses were carried out by elec- tron microscopy.Results After 20 d treatment with HOBT,diabetic caniiomyopathy was remarkably improved in STZ rats as compared with that of control group.Electron micrographs of ultrastructural observations on the cardio- myocytes showed well organized myofihrils and normal mitochondria at day 20.Conclusion HBOT can improve dia- betic cardiomyopathy in STZ-induced diabetic rats.更多还原