【摘要】 目的探讨系统性红斑狼疮继发干燥综合征（SLE-SSS）患者的⁹⁹Tc^mO₄^- 唾液腺动态显像特点。方法对42例 SLE-SSS 患者与10名健康对照者行常规⁹⁹Tc^mO₄^-唾液腺动态显像,获得并比较腮腺与颌下腺的时间一放射性曲线（TAC）及功能参数:15 min 摄锝率（UR）与酸反应泌锝率（SR）。结果在 SLE-SSS 组,21.4%的腮腺与59.5%（11.9%为单侧）的颌下腺 TAC 明显异常。SLE-SSS 组的 UR 与 SR 均值均低于对照组（P<0.01）,且左侧腮腺 UR 均值低于右侧（P<0.01）。SLE-SSS 组腮腺的 UR 及 SR 分别与颌下腺的 UR 及 SR 呈明显正相关（P<0.05）,腮腺及右侧颌下腺的 UR 与 SR 无明显相关性（P>0.05）,左侧颌下腺的 UR 与 SR 呈明显正相关（P<0.01和<0.05）。结论 SLE-SSS 时腮腺与颌下腺的摄取及分泌功能受损程度呈正相关,且颌下腺受损程度重于腮腺;腺体自身摄取与分泌功能受损程度无必然关联,且双侧腺体的功能受损程度不对称。更多还原

【Abstract】 Objective Dynamic salivary scintigraphy with ⁹⁹Tc^m-pertechnetate was used in the cur- rent study to assess the functional characteristics of salivary glands in patients with Sj（?）gren’s syndrome （SSS）secondary to systemic lupus erythematosus（SLE）.Methods Forty-two patients with SLE-SSS and 10 controls underwent the dynamic salivary scintigraphy with ⁹⁹Tc^m-pertechnetate.The time-activity curves （TACs）and functional parameters of parotid and submaxillary glands,including ⁹⁹Tc^m uptake ratio（UR） at 15 min and secretion ratio（SR）after citrate stimulus were obtained.Results In SLE-SSS group,TACs were obviously abnormal in 21.4% parotid gland and 59.5%（11.9% being unilateral）submaxillary gland.The UR and SR of SLE-SSS group were significant lower than those of controls（P<0.01）,while mean UR of the left parotid gland was lower than that of the right（P<0.01）.In SLE-SSS group,UR and SR of parotid gland positively con’elated with those of submaxillary gland（P<0.05）.The UR of parotid gland and right submaxillary gland did not correlate significantly with their SR（P>0.05）,but the UR of left submaxillary gland positively correlated with its SR（P<0.05）.Conclusions In SLE-SSS,the dam- age on uptake and secretion function of parotid and submaxillary glands were related,but the later more se- vere.No correlation was found between the uptake and secretion in single gland,and the functional damage to bilateral glands might be asymmetric.更多还原