【摘要】 目的对比¹⁸F-FDG PET/CT 和 CT 评价非小细胞肺癌（NSCLC）患者淋巴结转移及分期（N 分期）的价值。方法回顾性分析68例行根治性手术治疗的 NSCLC 患者资料(术前同期行增强 CT 和¹⁸F-FDG PET/CT 检查,术中清扫各站淋巴结),根据其术后病理检查结果,结合影像学诊断,比较 CT 和 PET/CT 对肺癌淋巴结转移的诊断价值及确定 N 分期的准确性。结果 CT 和 PET/CT 诊断纵隔淋巴结转移的灵敏度、特异性、准确性、阳性预测值（PPV）和阴性预测值（NPV）分别为63.6%,64.6%,64.3%,47.7%,77.8%与87.9%,87.7%,87.8%,78.4%,93.4%,差异均有统计学意义（P<0.05）;CT 与 PET/CT 诊断 N 分期的准确性分别为54.4%和76.5%,两者差异有统计学意义（P<0.05）。结论 ¹⁸F-FDG PET/CT 在诊断 NSCLC 纵隔淋巴结转移方面的临床价值高于 CT,能够更准确地确定 N 分期,指导治疗方案的选择。更多还原

【Abstract】 Objective This study was to compare the clinical value of ¹⁸-FDG PET/CT and chest CT alone in detecting regional metastatic lymph nodes and staging for patients with non-small cell lung canc- er（NSCLC）.Methods Enhanced chest CT and ¹⁸F-FDG PET/CT were performed in sixty-eight patients with NSCLC.Pathological findings were obtained through mediastinal lymph node dissection and tumor re- section.Clinical staging by CT alone and PET/CT was compared with pathological stages.Results For de- tecting mediastinal metastatic lymph nodes,the sensitivity,specificity,accuracy,positive predictive value and negative predictive value of CT alone and PET/CT were 63.6%,64.6%,64.3%,47.7%,77.8% and87.9%,87.7%,87.8%,78.4%,93.4%,respectively（P<0.05）.Fifty-two of 68（76.5%）pa- tients were correctly N-staged by PET/CT,while only 37 of 68（54.4%）by CT alone.Conclusion ¹⁸F- FDG PET/CT is superior over chest CT alone in detecting lymph node metastasis and determining N stage for NSCLC.更多还原