【摘要】 目的选择符合股骨骨髓腔解剖学特点、检查时间短、重复性良好而且图像质量高的MR 氢质子波谱（¹H-MRS）采集方法。方法采用1.5 TMR 单体素波谱激发回波探测序列对26名志愿者正常股骨骨髓进行¹H-MRS 的探索性研究。其中12名股骨¹H-MRS 采用128次采集、1 cm×1 cm×1 cm 大小的立方形感兴趣容积（VOI）在同一受检部位重复采集2～3次。另14例股骨¹H-MRS 分别采用128次和256次采集、1 cm×1 cm×1 cm 和2 cm×2 cm×2 cm 大小 VOI。结果采用1 cm×1 cm×1 cm 大小的 VOI 和128次采集获得的¹H-MRS 基线稳定,水半高宽≤8～12 Hz,信噪比为11.31,2～3次重复采集后谱线可重复率为100%。不同部位采集的¹H-MRS 表现不尽相同,最大波峰位置位于0.90 ppm(×10^-6)或1.65 ppm 附近处。但同一部位采用不同的 VOI 大小和不同的采集次数所获得的谱线全部相同或相似。¹H-MRS 采集时间与 VOI 大小无关,128次和256次采集时间分别为199 s 和391 s。结论采用1 cm×1 cm×1 cm 大小的 VOI 和128次采集股骨骨髓。¹H-MRS 具有临床可行性,采集时间较短,图像质量高而且重复性良好,具有较强的临床实用性。更多还原

【Abstract】 Objective To choose proper proton magnetic resonance spectroscopy（¹XH-MRS） parameters to fit for practical femoral marrow cavity and to produce short-timed,well-repeated and excellent ¹H-MRS images.Methods The tentative study of ¹H-MRS on the normal femoral bone marrow in 26 volunteers was performed with a 1.5 T MR after the informed consent.The single-voxel spectroscopy and stimulated echo acquisition mode were used for ¹H-MRS collection.¹H-MRS parameters for 12 volunteers were 128 acquisitions,1 cm×1 cm×1 cm volume of interest（VOI）size and repeatedly 2—3 times within the same location.¹H-MRS parameters for another:14 volunteers were different numbers of acquisition （128 and 256 times,respectively）and different VOI sizes（2 cm×2 cm×2 cm and 1 cm×1 cm×1 cm, respectively）.Results For ¹H-MRS with 1 cm×1 cm×1 cm size of VOI and 128 times of acquisition with the full width haft max of water≤8—12 Hz,the base-line was steady and the signal-noise ratio was high up to 11.31.¹H-MRS was different in the different femoral locations showing the maximum peak sites at near 0.90 ppm(×10^-6)or 1.65 ppm,but¹H-MRS within the same location was always same or similar with different VOI sizes（1 cm×1 cm×1 cm or 2 cm×2 cm×2 cm）or different numbers of acquisition（128 or 256 times）.¹H-MRS acquisition time was not related with the size of VOI but with the numbers of acquisition.128 and 256 times of acquisition cost 199 s and 391 s,respectively.Conclusion With the technique of small size of VOI（1 cm×1 cm×1 cm）and decreased numbers of acquisition（128 times）,it is propable to get well-repeated and excellent ¹H-MRS within less time.It is also more practical for clinics to achieve ¹H-MRS of the femoral marrow with the proper technique.更多还原