【摘要】 目的观察早期乳腺癌保乳术后常规放疗的美容效果及较远期疗效。方法进入研究的条件为单一病灶,肿块最大直径≤3 cm,显微镜下手术切缘阴性,腋窝淋巴结清扫为阴性。排除炎性乳腺癌和男性乳腺癌。42例0、Ⅰ、Ⅱ期乳腺癌保乳手术后使用6 MV X线切线野常规分割照射,全乳房照射50 Gy,局部瘤床区电子线补量照射10 Gy。治疗后2年内每3个月、第3-5年每6个月、之后每年随访1次,观察治疗和美容效果。结果全组病例随访19-90个月(中位随访56个月),2例分别在治疗后16、36个月因远处转移死亡,CT确诊。美容效果和患者满意度均超过93%。无一局部复发,局部控制率100%。1、3年生存率分别为100%、98%。结论早期乳腺癌保乳术后6 MV X线切线野照射疗效可靠、美容效果良好且急性和晚期毒性作用小,因此更有利于早期乳腺癌患者生活质量的提高。更多还原

【Abstract】 Objective To study the cosmetic outcome and curative effect of 6 MV X-ray tangential field radiotherapy for early stage breast cancer after conservative surgery. Methods The eligible criteria were single tumor≤3 cm in diameter, surgical margin negative and lymph node negative. The exclusive criteria were inflammatory carcinoma or male breast cancer. After conservative surgery, 42 patients with stage 0,ⅠorⅡbreast cancer were treated with conventional radiotherapy with a total dose of 50 Gy to the whole breast and 10 Gy boost to the tumor bed. The efficacy and the cosmetic outcome of radiotherapy were evaluated every 3 months for the first 2 years and every 6 months after that and every 12 months after 5 years. Results The follow up time was 19-90 months (median 56 months ). Two patients died of metastasis after 16 months and 36 months, which was diagnosed by CT scan. Excellent or good cosmetic outcome was >93% at 36 months. The local control rate was 100%. The 1- and 3-year survival rates was 100% and 98% , respectively. Conclusions Tangential field radiotherapy for early breast cancer after conservative surgery has a satisfied result in both tumor control and cosmetic outcome, which can definitely improve the life quality of the patients.更多还原