【摘要】 目的探讨胎肾细胞悬液对去卵巢(OVX)骨质疏松大鼠股骨、腰椎骨生物力学性能的影响。方法取3月龄未交配健康SD雌性大鼠39只,随机分为4组,即A、B、C、D组。A组行假手术,B、C、D组行OVX手术。术后12周,A、B组给予生理盐水,C组给予尼尔雌醇,D组给予胎肾细胞悬液。药物治疗4周后,对左侧股骨、第2腰椎骨分别行三点弯曲力学试验、压缩力学试验,测量生物力学参数,检测血清雌二醇水平。结果与A组比较,B组大鼠股骨、腰椎骨的生物力学性能下降(P<0.05),血清雌二醇下降(P<0.01);与B组相比,C组、D组股骨、腰椎骨的生物力学性能明显改善,血清雌二醇的水平升高(P<0.05);C组与D组差异无显著性(P>0.05)。结论胎肾细胞悬液能够改善去卵巢大鼠的骨生物力学性能,提高血清雌二醇的水平,作用与尼尔雌醇相似。说明胎肾有防治去卵巢大鼠骨质疏松的作用。更多还原

【Abstract】 Objective To explore the effects of fetal renal cell suspension（FRCS） on biomechanical properties of femur and lumbar vertebra in ovariectomized osteoporosis rats.Methods Thirty nine female Sprague-dawley rats,three months old,were divided randomly into four groups: SHAM group（group A）,OVX group（group B）,OVX+E group（group C）,and OVX+FNCS group（group D）.Twelve weeks after operation,the rats in group A and group B were treated with sodium chloride,the group C was treated with Nilestriol suspension,the group D was treated with FNCS,All rats were sacrificed after four weeks.The three-point bending test on the left femur and compression test on the second lumbar vertebra were performed,and serum estradiol（E₂） level was measured.Results The biomechanical property and the level of E₂ in group B were significantly lower than group A（P<0.05）.The biomechanical property and the level of E₂ in group C and group D were significantly higher than group B（P<0.05）.No differences were shown between group C and group D（P>0.05）.Conclusion FRCS is beneficial in improving the biomechanical property,and it can increase the level of E₂ of ovariectomized osteoporosis rats.These effects of FNCS were similar to the effects of Nilestriol.This study suggests that FNCS could effectively treat the osteoporosis of ovariectomized rats.更多还原