【摘要】 目的分析乳腺癌CerbB-2、PCNA的表达与腋窝淋巴结、肿瘤大小、年龄、病理类型的相关性。方法应用免疫组化Envison二步法对180例原发性乳腺癌行根治及改良根治术的标本进行了CerbB-2、PCNA的检测,并进行统计学分析。结果CerbB-2、PCNA的阳性表达率分别为35.6%(64/180)和41.7%(75/180);CerbB-2、PCNA的阳性表达率与淋巴结转移有关(P<0.01),而与患者年龄、肿瘤大小及乳腺癌组织学类型无关(P>0.05)。结论CerbB-2、PCNA的阳性表达与淋巴结转移程度呈正相关,与肿瘤大小、年龄、病理类型不相关。CerbB-2、PCNA可作为判断乳腺癌预后的指标。更多还原

【Abstract】 Objective To investigate the relationship between the expression of CerbB-2 and PCNA in breast cancer and the auxiliary lymph nodes,tumor size,age,pathological type of cancer in breast cancer patients.Methods Immunohistochemical two-step Envison method was used for the detection of CerbB-2 and PCNA in specimens taken from 180 breast cancer patients undergoing radical treatment or modified radical treatment.χ2 Statistical analysis was used.Results The positive expression rates of CerbB-2 and PCNA were 35.6%(64/180)and 41.7%(75/180)respectively,and the positive expression rates of them were associated with lymph node metastasis(P<0.01),but not related to patient’s age,tumor size,and histological type(P>0.05).Conclusion The positive expression rates of CerbB-2 and PCNA were related to lymph node metastasis,but not related to patient’s age,tumor size and histological type.They can be used to predict the prognosis of breast cancer patients.更多还原