【摘要】 目的:建立平行催化氢波测定依托度酸的新方法。方法:用氧化剂存在时依托度酸产生的极谱催化波提高分析灵敏度,用线性单扫描极谱法实现快速测定。结果:在磷酸二氢钾-磷酸氢二钠(pH5.5±0.1)支持电解质中,依托度酸产生一催化氢波,峰电位Ep=-1.23V。当1.0×10-2mol.L-1过氧化氢存在时,该催化氢波被催化,峰电流增加10倍,峰电位基本不变,产生一较灵敏的平行催化氢波。其二阶导数峰峰电流i″p与依托度酸浓度在2.0×10-7～6.0×10-5mol.L-1范围内呈线性关系(r=0.9987),检出限为1.0×10-7mol.L-1。结论:该方法可用于药物制剂中依托度酸含量的测定。更多还原

【Abstract】 OBJECTIVE To establish a polarographic method of parallel catalytic hydrogen wave for determination of etodolac.METHODS The catalytic wave of etodolac in the presence of H2O2 was used to improve the analytical sensitivity.The rapid determination of etodolac was realized by linear single sweep polarography.RESULTS The catalytic hydrogen wave of etodolac was measured at ca.-1.23 in 0.20 mol·L-1 KH2PO4-Na2HPO4(pH5.5±0.1)supporting electrolyte.When 1.0×10-2 mol·L-1 H2O2 is present,the current increased by 10 times,and the peak potentioal remained unchanged,producing a more sensitive parallel catalytic hydrogen wave.The peak current of the parallel catalytic hydrogen wave was rectilinear to the etodolac concentration in the range 2.0×10-7-6.0×10-5 mol·L-1(r=0.998 7).The detection limit was 1.0×10-7 mol·L-1.CONCLUSION The proposed method can be applied to the determination of etodolac in pharmaceuticals without preliminary separation.更多还原