【摘要】 目的:研究四川理县羌族地区产我国重要中药材羌活的化学成分,并比较与其他产地该药材之间的成分差别。方法:运用各种分离材料和方法分离羌活根的化学成分,采用波谱技术鉴定其结构。结果:从羌活根的70%丙酮提取物中分离得到12个化合物,经波谱解析分别鉴定为:notoptol(Ⅰ)、羌活醇(Ⅱ)、紫花前胡苷(Ⅲ)、镰叶芹二醇(Ⅳ)、(10E)1,10-heptadecadiene-4,6-diyne-3,8,9-triol(Ⅴ)、10-hydroxyverbenon(Ⅵ)、(+)-bornylferulate(Ⅶ)、孕甾烯酮醇(Ⅷ)、香草酸(Ⅸ)、香豆酸(Ⅹ)、反式阿魏酸(Ⅺ)和9,12-octadecadienoic acid(Z,Z)-(2,2-dimethyl-1,3-dioxolan-4-yl)methyl ester(Ⅻ),化合物Ⅰ~Ⅳ、Ⅶ和Ⅷ是其主要成分,化合物Ⅴ~Ⅶ和Ⅹ、Ⅻ为首次从该植物中分离得到。结论:四川理县产羌活的化学成分与其他产地的有所区别。更多还原

【Abstract】 AIM:To study the chemical constituents of Notopterygium incisum collected from Li county,Sichuan Province,and compare the chemical costituents of Notopterygium incisum between Li county,Sichuan province and other regions. METHODS: Isolating the chemical constituents of the rhizomes of Notopterygium incisum by all kinds of chromatography,and identifying their structures on the basis of spectral analysis. RESULTS: Twelve compounds were isolated from the rhizomes of Notopterygium incisum. Their structures were elucidated as notoptol(Ⅰ),notopterol(Ⅱ),nodakenin(Ⅲ),falcarindiol(Ⅳ),(10E)-1,10-heptadecadiene-4,6-diyne-3,8,9-triol(Ⅴ),10-hydroxyverbenon(Ⅵ),(+)-bornyl ferulate(Ⅶ),pregnenolone(Ⅷ),vanillic acid(Ⅸ),p-coumarin(Ⅹ),trans-ferulic acid(Ⅺ) and 9,12-octadecadienoic acid (Z,Z)-(2,2-dimethyl-1,3-dioxolan-4-yl) methyl ester(Ⅻ). Among them,compounds Ⅰ～Ⅳ,Ⅶ and Ⅷ are its main constituents;compounds Ⅴ～Ⅶ,Ⅹ and Ⅻ were obtained from this plant for the first time. CONCLUSION: There are some componential differences of Notopterygium incisum between Li county,Sichuan province and other regions.更多还原