【摘要】 目的测定多囊卵巢综合征(PCOS)患者的胰岛素敏感性(IS),并分析其相关影响因素。方法将观察对象分为PCOS肥胖组(10例)、PCOS非肥胖组(28例)和正常对照组(9例),IS用两步法高胰岛素-正葡萄糖钳夹技术评估。结果(1)PCOS两组患者的葡萄糖利用率M值明显低于对照组(P均<0.01),肥胖的PCOS患者M值降低更明显。(2)多元线性回归分析显示游离睾酮及BMI与M值负相关(P<0.05)。结论非肥胖和肥胖PCOS患者均存在明显的胰岛素抵抗,PCOS患者IS与游离睾酮及BMI密切相关。更多还原

【Abstract】 Objective To measure insulin sensitivity in patients with polycystic ovary syndrome(PCOS)and analyze its associations with correlative factors.Methods The subjects were divided into three groups:obese PCOS(n=10),non-obese PCOS(n=28)and control group(n=9).And the insulin sensitivity was assessed by two-step hyperinsulinemic-euglycemic clamp.Results(1)Insulin sensitivity(M value)was significantly lower in obese PCOS subjects than that in other two groups(all P<0.01).The M value in obese PCOS subjects was even more lower than that in non-obese PCOS subjects(P<0.05).(2)Stepwise regression analysis showed that M150～180 value was significantly associated with free testosterone(FT)and BMI.Conclusions Both non-obese and obese PCOS women have insulin resistance,and the insulin sensitivity of PCOS patients is negatively associated with serum FT and BMI.更多还原