【摘要】 目的探讨应用通过OGTT获得的简易葡萄糖处置指数(DI=ΔI30/ΔG30×1/HOMA-IR)评估多囊卵巢综合征(PCOS)患者胰岛β细胞功能的可能性。方法79例PCOS患者根据OGTT结果分为正常糖耐量(NGT)组(47例)和糖耐量减低(IGT)组(32例),分别行Botnia葡萄糖钳夹术,该钳夹术包括静脉葡萄糖耐量试验和高胰岛素-正糖钳夹术,DI=胰岛素敏感性×胰岛β细胞功能。结果(1)ΔI30/ΔG30×1/HOMA-IR与从钳夹术获取的DI呈正相关(NGT组r为0.51,P≤0.001;IGT组r为0.53,P<0.05)。(2)ΔI30/ΔG30×1/HOMA-IR与OGTT各时点血糖浓度呈负相关(P<0.05),且多元回归分析发现其对2hPG影响最大(回归模型P<0.0001)。结论ΔI30/ΔG30×1/HOMA-IR与Botnia葡萄糖钳夹术获取的DI呈正相关,线性相关性优于其他胰岛β细胞功能简易指数,可作为反映胰岛β细胞功能简单、有效的指标。更多还原

【Abstract】 Objective To explore whether simple glucose disposition index(ΔI30/ΔG30×1/HOMA-IR)obtained from OGTT is reliable for evaluating islet β-cell function in PCOS patients.Methods 79 subjects were given oral glucose tolerance tests(OGTT)and Botnia glucose clamp which was an intravenous glucose tolerance test(IVGTT)was followed by an euglycemic-hyperinsulinemic clamp.The subjects were divided into NGT and IGT group(47 vs 32 subjects).Glucose disposition index(DI)was calculated as the product of IS and βF(DI=IS×βF).Results(1)ΔI30/ΔG30×1/HOMA-IR showed positive linear correlation with DI(AIR×Clamp-IS)obtained from Botnia glucose clamp(NGT,r=0.51,P≤0.001;IGT,r=0.53,P<0.05).(2)ΔI30/ΔG30×1/HOMA-IR showed inverse linear correlation with the glucose level at 0,30,60 and 120min of OGTT(P<0.05),and it was the most significantly independent variable for 2hPG in stepwise regression analysis.Conclusions ΔI30/ΔG30×1/HOMA-IR shows better positive linear correlation with DI obtained from Botnia glucose clamp than other β-cell function indexes,so it is simple and reliable index for evaluating β-cell function in PCOS patients.更多还原