【摘要】 目的探讨C-erbB-2癌基因在膀胱癌中的表达与彩色血管能量成像(CPA)血流的关系。方法术前应用CPA检测50例膀胱癌患者及20例膀胱非肿瘤性增生患者的血流信号及其阻力指数RI,术后用免疫组化法术后测该组织中C-erbB-2的表达。结果C-erbB-2在膀胱癌中的阳性表达率为60%。显著高于非肿瘤性增生组(30%,P<0.05),C-erbB-2在II-III级膀胱癌阳性表达率(71%)显著高于0-I级(30%,P<0.05),C-erbB-2在T2-T4期的膀胱癌的阳性表达率(70%),显著高于Tis-T1(30%,P<0.05),膀胱癌的C-erbB-2表达强度与CPA血流分级呈正相关(r=0.677,P<0.05),膀胱癌的RI值(0.50±0.43)显著低于非肿瘤增生性组RI值(0.69±0.41,P<0.05),其表达强度与RI呈负相关(r=-0.537,P<0.05)。结论膀胱癌在C-erbB-2中的表达为临床应用CPA提供了可靠的病理学基础,而CPA则为临床诊断膀胱癌提供了敏感的血流信息。更多还原

【Abstract】 Objective To evaluate the relationship between C-erbB-2 expressions in bladder carcinoma and color power Doppler angio imaging（CPA） blood flow.Methods Fifty patients with bladder carcinoma and 20 cases with bladder hyperplasia underwent CPA preoperatively whereas C-erbB-2 was stained immunohistochemistry after operation.Results C-erbB-2 positive expression rate （60%） in bladder carcinoma was higher than that （30%） in hyperplasia group （P<0.05）,the C-erbB-2 positive expression （71%） in grade II-III was significant higher than that （30%） in grade 0-I （P<0.05）.Similarly,the expression in the stage of T₂-T₄（80%） was significant higher than that in the stage of T is -T₁ （30%,P<0.05）.The C-erbB-2 intensity of bladder carcinoma showed a positive correlation to the CPA degrees （r=0.677,P<0.05）.The RI value of malignant group was slightly lower than that （0.50±0.43 vs 0.69±0.41） of the hyperplasia group （P<0.05）.The intensity of C-erbB-2 showed a negative correlation to RI values （r=-0.537,P<0.05）.Conclusions The expressions of C-erbB-2 for bladder carcinoma may support CPA pathologically and the latter may provide in turn the sensitive blood flow information for the diagnosis of bladder carcinoma in clinical.更多还原