【摘要】 目的:探讨骨碱性磷酸酶(B-ALP)、白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)在去卵巢大鼠骨质疏松模型中的表达。方法:通过切除大鼠双侧卵巢,建立大鼠骨质疏松模型,分别于手术后2、3、4、5个月检测骨密度、骨碱性磷酸酶、白细胞介素-6及肿瘤坏死因子-α的变化。结果:与空白组和假手术组相比,去势组中骨密度显著降低(P<0.05),B-ALP、IL-6和TNF-α含量均显著增高(P<0.05)。结论:B-ALP、IL-6和TNF-α在去卵巢大鼠骨质疏松模型中显著表达,与骨质疏松发生程度成正相关。更多还原

【Abstract】 Objective:To research the significance of expressing of bone alkaline phosphatase (B-ALP),IL-6 and TNF-α in osteoporosis model.Methods:The osteoporosis model were established by bilateral ovariectomy. The bone mineral density (BMD), B-ALP,IL-6 and TNF-αwere detected respectively on 2,3,4 and 5 months after operation.Results:BMD was much lower (P<0.05), B-ALP,IL-6 and TNF-α were much higher in osteoporosis model than those in osteoporosis model (P<0.05).Conclusion:There are higher expressing of B-ALP,IL-6 and TNF-αin steoporosis model having obvious relation to the degrees of osteoporosis.更多还原