【摘要】 目的研究复方丹参注射液对急性脑梗死患者血清高敏C反应蛋白、基质金属蛋白酶-9水平的影响并探讨其与临床疗效的关系。方法86例急性脑梗死患者随机分为两组,治疗组予以常规措施并加复方丹参注射液治疗,对照组仅用常规治疗。血清hs-CRP采用免疫比浊法测定,MMP-9采用酶联免疫吸附测定法测定。结果两组治疗后血清hs-CRP、MMP-9浓度较治疗前均明显降低(P<0.001),但治疗组降低较对照组更显著(P<0.001);治疗组显愈率及总有效率显著优于对照组(P<0.05);两组治疗后较治疗前神经功能缺损程度评分均明显改善(P<0.001),但治疗组改善较对照组更显著(P<0.001)。结论复方丹参注射液可显著降低急性脑梗死患者血清hs-CRP、MMP-9水平,其对急性脑梗死的治疗作用与降低hs-CRP、MMP-9,减轻炎症反应有关。更多还原

【Abstract】 Objective To evaluate the therapeutic effect of compound Danshen injection for acute cerebral infarction and explore its influences on hypersensitive C-reactive protein and matrix metalloproteinase-9 in peripheral blood in patients. Methods 86 patients were randomly divided into two groups(n=43): the therapeutic group was given conventional therapy adding compound Danshen injection, while the control group was given conventional therapy only. Serum hs-CRP concentrations were examined by immunoturbidimetry and serum MMP-9 levels were examined by enzyme-linked immunosorbentassay. Results Serum hsCRP and MMP-9 levels all obviously decreased in the patients after treatment for two weeks(P<0.001), and the difference was more significant in therapeutic group than in control group(P<0.001). After treatment, the clinical curative rate and markedly effective rate were higher than those in the control group(P<0.05), and all the criteria tested decreased more significantly in the therapeutic group than those in the control group(P<0.001). Conclusion Compound Danshen injection has significant therapeutic effect for acute cerebral infarction and can markedly reduce the serum concentration of hs-CRP and MMP-9 in patients. The mechanism of compound Danshen injection in treating acute cerebral infarction is related with its action of anti-inflammation in the patients.更多还原